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Chemistry of fluorinated phosphonates

We have developed new methodologies for nucleophilic transfer of fluorine-containing groups using fluorinated phosphonates (Chemické Listy 108: 926, 2014).
  • Trifluoromethylation
    Diethyl trifluoromethylphosphonate affects trifluoromethylation of non-enolizable ketones to trifluoromethyl-containing alcohols. It also reacts with aldehydes to give phosphates of trifluormethylated alcohols (Tetrahedron Letters 51: 252–255, 2010).